Besides, it starts killing the fleas within 3 hours and . This product should only be used in dogs and puppies over 8 weeks and who weigh more than 2.8 pounds. Im just looking for advice as to tick prevention medication. Documented negative reactions were only provoked at higher-than-normal dosages and were comparatively mild, consisting of salivation, ataxia (dilated pupils), and depression. It sounds similar to a couple other natural oil products Ive tried. In summary, it looks like Parastar Plus is comparatively a gentler product than some topicals since the concentrations of its active ingredients are fairly low, but the trade-off may be that it lacks the strength of products like K9 Advantix II. It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. Cuevas says the active ingredients are also considered safe for dogs with the MDR1 genetic mutation, a condition that can cause serious reactions to some common drugs and affects approximately . Except for the warning about Cats who have close contact with collies, my impression was that you thought K 9 Advantix was safe and effective for Collies. Infected dogs should be treated with an adulticide to remove adult heartworms. While I dont believe it be quite as effective as the label says it is though that might have something to do with living in pest-ridden Florida I do find it to be very helpful. Maybe regular Interceptor would be fine since it doesnt contain Praziquantel, but its difficult to say exactly what your dog is reacting to. Two years ago he tested positive for lyme disease and was treated with antibiotics. Second, Id like to ask a question if you dont mind. It has the same active ingredients as Seresto (plus one), so a bit stronger. Its in lots of grain-based foods because lots of grains are stored with diatomaceous earth to keep the bugs from eating the grain.. My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. (I didnt find the information about the 6 reported seizures until after I had already given it to my dogs and seen no ill effects from it.) The key to getting this spray to work well is to apply it well (rub against the lay of the coat while spraying the roots of the hair to get down to the skin); thoroughly (to the underbelly, legs, and paws); and often (at least once a week, more if your dog gets wet). (Some of the links lead to peer-reviewed scientific articles, so have fun with those if you want the bare, dusty facts.). Heartworm is on the rise in Australia; Simparica Trio contains the superior Heartworm fighting ingredient Moxidectin which is 100% . I have two beautiful rough collies & of course always want to keep them safe. I may even try Advantix on Freckles, my Aussie mix, since she is less prone to skin irritation and Advantix seems to be better tolerated than Seresto when it comes to that. Mary. My Vet told me Trifexis was safe to give them. Dogs with the MDR1 mutation are at risk of serious drug toxicities at doses that are safe to other dogs. Thank you for your very informative article. Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? I cant promise that it will be 100% effective, and one or two ticks may still latch on but Ive seen zero ticks on my dogs since I started using the Natural Chemistry spray in conjunction with Frontline Plus. And its always nice to meet someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (crazy?) Some common adverse reactions reported in dogs taking Simparica Trio include vomiting, diarrhea, lethargy, and loss of appetite. I like Frank so much that I had to give him his own story. We have always used Frontline Plus, but it has recently started causing dandruff on our dog, and it makes his coat greasy. I asked the vet for an alternative and was recommended Seresto collar or Vectra 3D. Thank you very much! We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. Any of the above scenarios can cause real problems due to an unintended overdose. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. The FDA approved Nexgard for flea treatment in dogs in September 2013, Bravecto in May 2014, Simparica in February 2016, and Credelio in January 2018. Since switching to Bravecto about 1.5 yr ago, zero ticks on either dog! (Theres also a hyperlink to her article.) Thank you thank you thank you for this article. Safe in breeding, pregnant and lactating dogs. The manufracturers website lists many different kinds of ticks, and people on this thread talk about using FrontLine for ticks. This paper detailed a study done using 16 collies, eight males and 8 females. I have a 3 year old and an 11 week old Australian Shepherd. I just had my vet mention the mdr1 gene today in passing. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. Hi! Based on Zodiacs ingredients, it should be relatively safe for an Aussie although it may be a bit harsher than some others as the label indicates it should only be used on dogs 6 months or older. Great summary! Thank you so much for writing this article!!! (Also, bear in mind that the Permethrin in Zodiac Spot On will make it very dangerous, even toxic, to cats, in case you have any.) Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. Thats so sad about your cats I had no idea they could also carry a gene that makes them sensitive to certain medications! I had never heard of Dimmitrol before, but I did some research after reading your comment. Quick Navigation (Same active ingredients in both.) Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. Just want to do what is best for them? Thank you for this. Simparica (sarolaner) Chewables are safe, monthly flea and tick protection for dogs that start working fast and remain effective all month long. (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes.) The vet is really no help. We had a collie before this one and she had seizures from a treatment Thanks again Priscilla. Advantage takes care of fleas at all life stages and is even supposed to kill them on contact, and it also covers lice. Personally I use Frontline Plus and supplement weekly with a Natural Chemistry spray as a repellent, but I understand that might not be ideal for everyone depending on their situations. (The Environmental Protection Agency is responsible for approving external flea and tick products.) (1) Use a natural brewer's yeast + garlic supplement (2) Use a natural flea & tick spray on your pet daily during warm months (3) Treat your yard using a natural product such as diatomaceous earth or Wondercide (4) Check your australian shepherd daily (during warmer months) for fleas and ticks. Comes as: a vial of liquid applied to the back of the neck on a monthly basis (fipronil) Used for tick control every two weeks if travelling to the eastern states. Based on your recommendations, I will not use Vectra. (More on those later.). Trish. However, I think your plan to take the collar on and off was probably the best way to give it a safe trial period. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. However, the safety of Interceptor Plus has not been evaluated for pregnant or lactating dogs, and it is not recommended for cats. For instance, dogs without any drug sensitivities, can take doses of ivermectin as high as 400 g/kg safely; whereas, in a dog with the MDR1 mutation, a dose as low as 50 to 100 g/kg is toxic. One person commented that their Collie had irritation at the point of contact, so they recommended checking frequently to make sure the collar is not irritating the skin. Thats what Im doing for my most recent Collie. Im trying to find out if this is safe for her. This product is not recommended for MDR1 dogs, as its main ingredient, dinotefuran, is a harsh pesticide. This article from Your Dog Advisor gives more natural prevention options and even tells you how to mix your own parasite preventives using essential oils and water. (If you order online, keep in mind that the company will first have to contact your veterinarian for a prescription to be issued, which may slightly delay the shipping time.). No treatment-related clinical signs were observed. Since I recommend being careful about using Simparica, I would be even more careful about using the more potent Simparica Trio. No adverse effects were observed. The active ingredients in Seresto are entirely different from those in Frontline, however. What can trigger a seizure in a dog? Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. they have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. For me, every medicine has its side effects, and it really comes down to weighing the risk of side effects against the risks posed by parasites. Please keep me updated if you think of it! If a spot-on treatment is applied between the neck and shoulders as directed, no harm should befall a dog; but if its applied past the shoulders where a dog can reach with its tongue, that could definitely cause problems. This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. Unfortunately, both my Collies and to a lesser extent my Aussie mix have some skin sensitivities: so K9 Advantix II and Seresto, while very effective, would most likely cause them skin irritation. For those who like Advantage but are concerned about ticks on their dogs, the Preventic Tick Collarcan be worn for additional protection. My plan is to adopt a senior Border to go with my lazy Roughs. In hot, flea-infested areas like where I live in Florida, Parastar Plus might not be the best option; but its definitely something I would have tried when I still lived in Michigan. It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. . I tried to review a variety of the most well-known parasite protection products out there, but if I left out any you are curious about, leave a comment below! (I have to give them baths with a very mild or medicated shampoo.) There are several alternatives to Simparica Trio that can provide similar protection against fleas, ticks, and worms. Is Simparica Safe For Dogs? Wow! I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. Personally, I would be concerned about missing a daily dose. The most common side effect of Simparica is vomiting, which can happen within the first hour or two after administration. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. It is safe for use with anthelmintics like heartworm meds and has no known negative drug-drug interactions. (This is for all dogs, not just for dog breeds at-risk for MDR1.) Hello, You mentioned ADVANTIX should be use with caution because of cats being around collies, but what about if I only have collies? Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? Ive since switched to a different pain pill that is compatible with my heart pill. Advantage Multi can be a great product when used with care, and I would expect the same to be true for Advocate. My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. Thank you for this. As with any topical, of course keep an eye out for skin irritation. Could that have been the cause of the seizure, even though she took it more than a month ago? Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. Thank you for writing this article. According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. Are you also on Instagram, by chance? Hope this helps! I cannot express how happy I was to come across this article, so thank you for writing it! Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? However, not all MLs are created equal, and some are safer than others. I have a cat myself, so I appreciate the information. Some swear by food grade DE (diatomaceous earth) as a natural dewormer of roundworms, hookworms, whipworms, and even tapeworms. Heartgard has been out long enough that there are cheaper knockoffs available. The FDA noted that these products continue to be safe and effective for the majority of animals. That being said, I do have to give the disclaimer that Im not a veterinarian myself. Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. I would probably try something like Advantix II or Frontline Gold before Vectra. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. Thank you for bringing this to my attention! Happy to help! If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels . I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. 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