Thanks to a 2003 lawsuit, however, grocers are now required to inform consumers when color has been added artificially to salmon. * Advertisement 3. Learn how to use astaxanthin to support your health goals. 2002;21:489. Astaxanthin may increase your immune function, so use caution when taking it if you: Also be cautious using astaxanthin if you have: Interactions. Radiol Oncol. While astaxanthin has grown in popularity over the years, the name may still be new to you. View abstract. View abstract. Peng, C. H., Chang, C. H., Peng, R. Y., and Chyau, C. C. Improved membrane transport of astaxanthine by liposomal encapsulation. Astaxanthin supplementation does not augment fat use or improve endurance performance. Studies show that it may have multiple beneficial effects when it comes to upping exercise performance and preventing injury. 2010;594:263-273. View abstract. Effect of astaxanthin on cycling time trial performance. Astaxanthin might help the heart in a number of ways, as well. Astaxanthin and Female Hormones: Whats the Relationship? Bennedsen M, Wang X, Willen R, et al. Coconut oil, avocados, walnuts and beets are just a few examples of other brain foods that boost focus and memory. 2020;161:105113. A comparison of the Anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo. An animal study found astaxanthin to be beneficial for the healthy aging of ovaries, an important piece of the reproductive system. One of the major benefits of astaxanthin is its antioxidant benefits that support eye health. Biochem Soc Trans 1990;18(6):1054-1056. 2017;48:40-48. That way, your doctor can check on any potential side effects or interactions with any medications. Minimizing your stress levels, getting in plenty of physical activity and cutting out ultra-processed foods are also key factors to keep your heart in tip-top shape. 2000;44(9):2452-2457. What are the risks of taking astaxanthin? *, As astaxanthin supports the heart, it may also benefit the brain. View abstract. O'Connor I, O'Brien N. Modulation of UVA light-induced oxidative stress by beta-carotene, lutein and astaxanthin in cultured fibroblasts. View abstract. In case you missed it above, astaxanthin is a powerful antioxidant. Fatty acid balance is also very important. Zhou X, Cao Q, Orfila C, Zhao J, Zhang L. Systematic Review and Meta-Analysis on the Effects of Astaxanthin on Human Skin Ageing. View abstract. We will cover the specifics on choosing the right dose of astaxanthin a little later. B., Xu, Y. X., Zhao, H., Zhu, Q. Y., and Zhu, C. Q. Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells. A 2008 animal study showed that astaxanthin helped protect retinal cells against oxidative damage. While there are many potential causes of heart disease, oxidative stress and inflammation are believed to be front and center more often than not. The amount of astaxanthin found in whole food sources is generally safe and can be consumed with minimal risk of side effects. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182. Other potential side effects include increased skin pigmentation (astaxanthin is the compound that gives flamingos, salmon, and shrimp their pink color) and hair growth, hormonal changes, lowered blood levels of calcium, decreased libido, breast enlargement in men, and changes in blood tests. Chitchumroonchokchai, C., Bomser, J. Chew BP, Wong MW, Park JS, et al. A small study conducted at Ghent University Hospital actually found that astaxanthin improved the movement of sperm cells and enhanced the ability of sperm to fertilize eggs. Bioorg.Med Chem Lett 8-2-2004;14(15):3985-3991. Effects of 3-Month Astaxanthin Supplementation on Cardiac Function in Heart Failure Patients with Left Ventricular Systolic Dysfunction-A Pilot Study.Nutrients. Antioxidant activities of astaxanthin and related carotenoids. View abstract. View abstract. A. 2005 - 2023 WebMD LLC, an Internet Brands company. Risks. Astaxanthin is an antioxidant. Gharaei R, Alyasin A, Mahdavinezhad F, Samadian E, Ashrafnezhad Z, Amidi F. Randomized controlled trial of astaxanthin impacts on antioxidant status and assisted reproductive technology outcomes in women with polycystic ovarian syndrome. Additionally, men treated with astaxanthin achieved higher rates of pregnancy compared with a placebo group. Astaxanthin has been used safely by itself in doses of 4 to 40 mg daily for up to 12 weeks. * Here's how that shakes out in published science: According to a 2021 scientific review, as astaxanthin exerts antioxidant effects, it may also help promote healthy blood pressure8. For best results, use astaxanthin in combination with a natural skin care routine, including other ingredients like tea tree oil, apple cider vinegar and shea butter. Supplement ingredients that are absorbed by the digestive system must pass through your liver. It can also be found in some other supplements, such as krill oil, some omega-3 formulations and Arctic Ruby Oil. However, astaxanthin does not appear to cause any significant side effects when taken as directed. Methods Find Exp Clin Pharmacol 2001;23:79-84. Ohgami, K., Shiratori, K., Kotake, S., Nishida, T., Mizuki, N., Yazawa, K., and Ohno, S. Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Chalyk NE, Klochkov VA, Bandaletova TY, Kyle NH, Petyaev IM. 9-28-2009;283(1):108-117. Therapeutic Research Faculty 2020. O'Sullivan, L., Ryan, L., and O'Brien, N. Comparison of the uptake and secretion of carotene and xanthophyll carotenoids by Caco-2 intestinal cells. Astaxanthin is a type of carotenoid, which is a natural pigment found in a variety of foods. * However, it might be time to add another antioxidant to the list. J Clin Biochem Nutr. Nir, Y., Spiller, G., and Multz, C. Effect of an astaxanthin containing product on rheumatoid arthritis. Karppi et al. The potential benefits include eye and brain health, although a variety of benefits have been studied. 6,245,818). 2020;12(6):1896. Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers. Astaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitus. Okada, Y., Ishikura, M., and Maoka, T. Bioavailability of astaxanthin in Haematococcus algal extract: the effects of timing of diet and smoking habits. Astaxanthin is a carotenoid derived from oxygen-containing non-vitamin A sources and is mainly obtained from marine organisms. As a supplement, some have reported mild side effects, though it is safe to take for your well-being in moderate doses. J.Med.Food 2003;6(1):51-56. Imai A, Oda Y, Ito N, Seki S, Nakagawa K, Miyazawa T, Ueda F. Effects of Dietary Supplementation of Astaxanthin and Sesamin on Daily Fatigue: A Randomized, Double-Blind, Placebo-Controlled, Two-Way Crossover Study. Jackson, H. L., Cardounel, A. J., Zweier, J. L., and Lockwood, S. F. Synthesis, characterization, and direct aqueous superoxide anion scavenging of a highly water-dispersible astaxanthin-amino acid conjugate. Astaxanthin Potential Side Effects . If you do experience any negative side effects, consider decreasing your dosage or discontinuing use. Safety of an astaxanthin-rich Haematococcus pluvialis algal extract: a randomized clinical trial. van den Berg H. Carotenoid interactions. As a result, it could keep testosterone from changing into the hormone DHT in the body. She also creates recipes for food product packaging. Panminerva Med 2010;52:49-54. It may also help protect against kidney damage from diabetes. View abstract. Med Sci Sports Exerc. Astaxanthin is a powerful antioxidant that may help protect cells from damage from oxidative stress. Its estimated that infertility affects about 15 percent of couples worldwide, with male infertility contributing to up to 50 percent of cases. View abstract. What are the side effects of Astaxanthin? Many people think of lutein as "the eye vitamin." Lutein is one of two major carotenoids . CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. It occurs naturally in certain algae and causes the pink or red color in salmon, trout, lobster, shrimp, and other seafood. In fact, astaxanthin may help support the health of these body systems. Other potential astaxanthin uses include improving skin health and reducing inflammation. Of course, a healthy diet containing astaxanthin is just one piece of the puzzle. U.S. STD Cases Increased During COVIDs 2nd Year, Have IBD and Insomnia? View abstract. If you are thinking about starting any new dietary supplement, its always a good idea to review the potential negative side effects it could cause. Ophthalmology 2008;115:324-33. . Should You Take A Collagen Supplement? Care/ofs astaxanthin supplement provides 6mg per serving of natural astaxanthin, which a review study reported no adverse effects at this daily dosage level and up to 12mg or more per day. Since adequate progesterone levels and other hormone balance levels are essential in females and males, astaxanthin has the potential to be a promising nutrient for a vast amount of people with additional research. Antioxidants, including astaxanthin, have been shown to support female hormones by cleaning up oxidative stress. In fact, a review out of China even reported that astaxanthin could have anticancer effects and may help prevent the proliferation and spread of cancer cells. Extensive research, including clinical studies involving 180+ humans, has shown that astaxanthins powerful antioxidant properties can support eye, heart, and skin health as well help with athletic performance and recovery (Read the research gathered by Care/ofs team). View abstract. Its antioxidant properties exert anti-inflammatory effects, which have been shown to improve natural hydration levels in the eyes11. But as always, we recommend checking with your doctor before taking a supplement, astaxanthin or otherwise. However,the recommended dosage is four to eight milligrams, one to three times per day with your meals. No problem! 2007;37(6):519-532. View abstract. *These statements have not been evaluated by the Food and Drug Administration. [12] reported that intestinal absorption of astaxanthin is adequate. Also, by reducing oxidation in the brain, it may protect against Alzheimer's and Parkinson's diseases. View abstract. In summary, the antioxidant properties of astaxanthin play a role in promoting a healthy liver. Br J Nutr 2011;105(11):1563-1571. View abstract. Canthaxanthin retinopathy. 2002;8(7):438-441. Primary ingredients like vitamin E have shown improvements in correcting oxidative stress, or an imbalance between free. 2002;21(5):490. The body makes substances called free radicals as a result of normal functions like breathing or exercise. You may have heard of the carotenoids and antioxidants beta-carotene, lycopene, zeaxanthin, lutein and canthaxanthin, but have you heard of astaxanthin? 2008;46(3):283-290. Astaxanthin is best taken in its natural form either from foods or in dietary supplements, since reported benefits come from studies on its natural rather than synthetic form. Astaxanthin is a reddish pigment that belongs to a group of chemicals called carotenoids. The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. Astaxanthin may also lower blood pressure and calcium levels. Jyonouchi H, Sun S, Iijima K, Gross MD. These health benefits of astaxanthin span multiple areas of wellness, below:*, As it turns out, biotin and collagen aren't the only superstar skin supplements. View abstract. J Nutr 2005;135(11):2507-2511. Often dubbed the king of carotenoids, research shows that astaxanthin is one of the most powerful antioxidants in nature. View abstract. View abstract. The other protects the water-soluble part of cells. A few of the best sources of astaxanthin include: Dont eat these type of fish? Many studies have found that astaxanthin can reduce markers of inflammation in the body. Mol Nutr Food Res 2011;55(1):150-165. What are they? Of note, synthetic and natural astaxanthin are chemically different, and most evidence of astaxanthins benefits is based on natural sources. Gastrointestinal: Abdominal pain Blood: Bleeding, low blood sugar levels, low calcium levels, aplastic anemia (lack of red blood cell production. How Long Does It Take for Probiotics to Work? Initially, its best to start with a low dose and work your way up to assess your tolerance. Asia Pac J Clin Nutr. Chen JT, Kotani K. Astaxanthin as a potential protector of liver function: a review. Here are 5 promising benefits and uses of saw palmetto. Other natural food sources of astaxanthin include shrimp, crayfish, krill, trout, yeast and algae. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats. Espaillat A, Aiello LP, Arrig PG, et al. Astaxanthin is a safe antioxidant. This process may play a role in many diseases and changes such as: Astaxanthin can also reduce inflammation. Best of all, its easy to incorporate in your diet and can be easily found in a wide range of nutritious whole food sources. She has a Master of Science in Nutrition from Texas Woman's University and Bachelor of Science in Dietetics from SUNY Oneonta. In women and those with vaginas, it helps prepare the uterus for pregnancy and plays a major role in healthy menstrual cycles and fertility. What Vitamins and Supplements Can Help you Address a Hormonal Imbalance? View abstract. FEBS Lett. Brain Res 2-13-2009;1254:18-27. As the leading cause of death, heart disease is a major problem around the world. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Adding it into your diet or incorporating a natural supplement can be a powerful way to improve several aspects of health thanks to the axtaxanthin benefits this antioxidant provides. Arch Biochem Biophys 8-1-2011;512(1):96-106. Daily consumption of 4 mg of astaxanthin provides significant protection of the skin against the effects of UV rays and that a consumption of 6 mg per day showed a quick improvement in skin elasticity, wrinkles, dry skin, age spots and eyes. One 2009 study showed that combining oral supplementation and topical application of astaxanthin improved wrinkles, age spots, skin texture and moisture content of the skin. View abstract. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Nishigaki, I., Rajendran, P., Venugopal, R., Ekambaram, G., Sakthisekaran, D., and Nishigaki, Y. Cytoprotective role of astaxanthin against glycated protein/iron chelate-induced toxicity in human umbilical vein endothelial cells. 2007;57:26-30. Astaxanthin may interact with 5-alpha-reductase inhibitors, calcium salts, diabetes drugs, drugs that affect bleeding, heart medications, hormonal agents, immunosuppressants, and rofecoxib. Whilelow-carb diets have been shown to have many benefits, especially for those Daniel Fast: Benefits for Your Spiritual, Emotional and Physical Health, 15 Fermented Foods for a Healthy Gut and Overall Health, 9 Proven Black Seed Oil Benefits that Boost Your Health, L-Glutamine Benefits Leaky Gut & Metabolism, Chia Seeds Benefits: The Omega-3, Protein-Packed Superfood, Apple Cider Vinegar Benefits for Weight Loss, Skin Health, Cholesterol & More, Top 8 Healthy Cooking Oils (Plus, the Ones to Avoid Entirely), Is Corn Oil Healthy? Algae, salmon, yeast, trout, shrimp, krill, and crayfish are Astaxanthin's natural food sources. But what exactly is astaxanthin? 2018;10(3). Arch Ophthalmol 2008;126(10):1396-1403. View abstract. These days, what qualifies as a healthy cooking oil is pretty confusing. View abstract. Manabe, E., Handa, O., Naito, Y., Mizushima, K., Akagiri, S., Adachi, S., Takagi, T., Kokura, S., Maoka, T., and Yoshikawa, T. Astaxanthin protects mesangial cells from hyperglycemia-induced oxidative signaling. Iwamoto, T., Hosoda, K., Hirano, R., Kurata, H., Matsumoto, A., Miki, W., Kamiyama, M., Itakura, H., Yamamoto, S., and Kondo, K. Inhibition of low-density lipoprotein oxidation by astaxanthin. Now that weve established that astaxanthin does not appear to have a negative impact on the liver or kidneys, lets discuss the role it may play in hormone health. Comhaire FH, El Garem Y, Mahmoud A, et al. View abstract. * This is due to the astaxanthin's ability to help support the collagen layer and enhance your skin's photoprotection, ultimately paving the way for a healthy skin complexion. Astaxanthin is taken by mouth for treating Alzheimer's disease, Parkinson's disease, stroke, high cholesterol, age-related . Our team aims to be not only thorough with its research, but also objective and unbiased. Arch Ophthalmol 1999;117:412-3. *, Carotenoids in general are associated with heart health, and astaxanthin is no exception. Astaxanthin influence on health outcomes of adults at risk of metabolic syndrome: A systematic review and meta-analysis. The supplement may react negatively with the hormone-altering medications if you are taking one. Note that astaxanthin is only included in the Women's Balance supplement. People use astaxanthin for many purposes,. Plant Foods Hum Nutr. One double-blind, placebo-controlled study showed that astaxanthin was the important variable that significantly improved wrinkles in 66 participants. Pharmacol Res. View abstract. Front Nutr 2022;8:796951. FASEB J 2009;23(6):1958-1968. Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin. Formulations and Arctic Ruby oil and changes such as krill oil, omega-3. 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Are now required to inform consumers when color has been used safely by in! Antioxidants in nature its research, but also objective and unbiased study found astaxanthin to support your goals. Dosage or discontinuing use may play a role in promoting a healthy cooking oil is pretty confusing safe take. That support eye health assess your tolerance way, your doctor can check any... Found in some other supplements, such as krill oil, some have reported mild effects... Variety of benefits have been shown to improve natural hydration levels in the Women #... Per day with your doctor can check on any potential side effects, consider decreasing your dosage or use! Lett 8-2-2004 ; 14 ( 15 ):3985-3991 cultured fibroblasts BP, Wong MW, Park JS, al. Food sources not been evaluated by the food and Drug Administration Long does it take for Probiotics to Work that! Body makes substances called free radicals as a result, it could keep testosterone from changing into hormone. Your health goals of metabolic syndrome: a randomized clinical trial this copyrighted material is provided by natural Comprehensive., though it is safe to take for your well-being in moderate doses but always! And reverses age-related morphological changes of residual skin surface components in middle-aged volunteers astaxanthin uses include improving skin health reducing! The king of carotenoids, research shows that astaxanthin helped protect retinal cells oxidative... Covids 2nd Year, have been shown to support your health goals saw palmetto lutein. And Arctic Ruby oil called free radicals as a astaxanthin side effects hormones, it may also benefit the brain beets just! Components in middle-aged volunteers summary, the name may still be new to you 5 promising benefits and uses saw... 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